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MiSAC News
Microbiology in Schools Grant

MiSAC has announced a new scheme by which UK schools and colleges can apply for funds from a total grant of £5000 to improve the study of microorganisms in their establishment. The £5000 will be divided into individual sums of £250, with one or two grants of £1000. All bids will be 'open', so that schools can specify items or services that they need. Click on the new 'Microbiology grant' Button for all the details.

MiSAC Publicity leaflet

MiSAC has produced a publicity flyer (PDF) to promote all of its activities in schools, both in the UK and internationally. Click image to download the publicity leaflet.

New publications

The collection of MiSACmatters articles has been extended by three new publications (36-38), written by Tansy Hammarton, which provide an introduction to molecular biology approaches in parasitic protozoa: 1. Investigating gene function in protozoan parasites - general approaches and challenges; 2. Molecular genetic methods for analysing gene function in protozoan parasites; 3. Visualising proteins in protozoan parasites.

Microbes in the News

New Scientist occasionally prints stories of the activities of microbes which provide interesting reading. Printed here are résumés of recently-published articles. For subscribers, a link is provided to the original source.

Gut reactions NEW

Our microbiome – the trillions of bacteria, fungi and viruses that inhabit our body, mainly in the gut, – has been linked to good physical and mental health. For years, maintaining a healthy microbial diversity in the gut has involved the use of probiotics (live bacteria) and prebiotics (food for beneficial microbes). Now, consuming postbiotics (dead and fragmented microbes + chemicals that live microorganisms have secreted) is increasingly involved to keep us healthy. If the gut microbiome is likened to a natural pharmacy, the postbiotics are the medicines it dispenses.

A short-chain fatty acid, butyrate, is a metabolite produced when gut microbes consume indigestible fibre, and has a role in developing food tolerance in young children. It also reduces inflammation in bowel diseases and can help treat food allergies. Urolithin A (UA) is produced when gut microbes feed on foods such as walnuts, strawberries and pomegranates. UA helps maintain functioning mitochondria, which decline with ageing. It is now available as a food supplement to help older people with osteoarthritis. These and another postbiotic supplement which reduces the risk of cardiovascular disease and diabetes point to a future with exciting dietary possibilities.

Click here for the original article.

Feed your immunity NEW

Many foods claim to help your natural defences against infection; supermarket shelves are heaving with "immunity support" juices, teas and yoghurts. What should you eat to strengthen your immune system? Evidence suggests that you concentrate on your overall diet: a "Mediterranean" meal rich in vegetables, fruit, nuts and olive oil is healthier than a "Western" diet, loaded with sugars and saturated fats but low in fibre and vegetables. Your diet appears to affect the microbiome – the vast bacterial community that lives in our gut. A fast-food diet of burgers and fries increases inflammation, whereas the Mediterranean diet damps down these responses.

The fermentation action of the gut bacteria on a high-fibre diet produces short-chain fatty acids (SCFAs) which are anti-inflammatory. Eating larger amounts of fermented foods, such as kimchi, kombucha and yoghurts, increases a more-diverse microbiome and decreased markers of inflammation. Beneficial microbes such as Bifidobacterium influence immunity via the secreted SCFAs which bind to immune cell receptors and prompt them to release signals that favour immune restraint over reactivity.

Click here for the original article.

A virus's link to causing multiple sclerosis

It has been suspected for some time that the common Epstein-Barr virus can trigger multiple sclerosis (MS). A study of 10 million military personnel in the USA has shown that virtually every case of diagnosed MS is preceded by an infection by the virus, which is spread via saliva, for example, in kissing. Initial infections by the virus may cause few, if any, symptoms but, once it enters the immune B cells, the virus lurks there permanently. Producing a vaccine against Epstein-Barr could reduce the incidence of MS.

Almost everyone has been infected by the Epstein-Barr virus so it is difficult to show that it is the trigger for MS. However, in the 10 million US personnel studied, 955 developed MS. Only one of the soldiers who developed MS tested negative for antibodies against Epstein-Barr.

Click here for the original article.

Edible straws made by bacteria beat plastic and paper

Cellulose is produced by many types of bacteria when they feed on sugars. Researchers air-dried the cellulose and dipped it into sodium alginate, a carbohydrate found in algae. This fills in the holes in the cellulose structure that would otherwise absorb water. The alginate allows flat sheets of the bacterial cellulose to be rolled up into straws and hold its shape without glue.

The bacterial cellulose straws biodegrade faster than plastic, don't release microplastics and don't go soggy and bend which paper straws are prone to do. Because bacterial cellulose and sodium alginate are already used in food products, they are quite safe and edible. Compared with other biodegradable straws, these new bacterial products cost 0.3 US cents per straw - the same as plastic straws and one-tenth the cost of paper ones.

Click here for the original article.

Long-haul fight

Alongside the 5.8 million people who have died from the Covid-19 virus, tens of millions more have long covid: a lingering condition with more than 200 symptoms that last for months or years. These include shortness of breath, post-exercise exhaustion and "brain fog". Many "long haulers" complain they have had little help from doctors. We now know that certain people are more at risk: if they have type 2 diabetes, if they have "autoantibodies" attacking their tissues, if pieces of the virus's genome are still circulating in their blood and if they have previously been infected with Epstein-Barr virus.

The theory of Covid viruses lingering in the body is supported by the reduction of symptoms when monoclonal antibody vaccinations are given to long covid sufferers. Evidence for immune disruptions is overwhelming with immune chemicals being overproduced, creating chaotic interactions in brain chemicals. Evidence is growing of the accumulation of "microclots" which restrict the flow of oxygen and nutrients to tissues and damages the walls of blood vessels. When drugs were administered to prevent the microclots from forming or to 'dissolve' them, the long covid symptoms of shortage of breath, fatigue and brain fog were reduced.

Click here for the original article.

More than just a phage

Bacteria which cause food poisoning are a grave health risk, not least because many have developed resistance to antibiotics. The main concerns are salmonella, listeriosis, shigella and pathogenic strains of Escherichia coli. Bacteria-killing viruses, called bacteriophages, are now being used to destroy harmful microbes during food processing, stop food rotting to extend its shelf life or treat diseases on farms.

Bacteriophages are extremely common; an estimate of their number on Earth is 1031. They are sprayed as a mist over food which may have been contaminated by food-poisoning bacteria such as Listeria monocytogenes. A cocktail of different types is often required because each phage targets only one specific bacterial strain, so several are needed to deal with all the strains which might be present. The phages destroy the bacteria but are harmless to humans and do not affect the taste or texture of food, unlike treating food with ionising radiations.

In Belgium, a woman with severe leg injuries became infected with the bacterium Klebsiella pneumoniae that is resistant to almost all drugs. As a last resort, she was treated with phage therapy developed against this bacterium and, within weeks, the wound started to heal.

Click here for the first original article.

Click here for the second original article.

Click here for archived news items
             
Blue tongue virus Pseudomonas fluorescens Oxytricha sp. Penicillium chrysogenum Microasterias sp.
Blue tongue virus   Pseudomonas fluorescens   Oxytricha sp   Penicillium chrysogenum   Microasterias sp
   

Sponsors:
British Mycological Society; British Society for Parasitology;CLEAPSS; Microbiology Society; NCBE; The Quekett Microscopical Club; SSERC

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